• Cyclopamine as a Smoothened Receptor Antagonist in Develo...

  2025-09-19

  Explore the multifaceted applications of cyclopamine, a potent Hedgehog signaling inhibitor, in developmental biology and cancer research. This article highlights its mechanisms as a Smoothened receptor antagonist, its effects in breast and colorectal cancer models, and its utility in teratogenicity studies.

• Rucaparib (AG-014699): Modulating DNA Damage Response in ...

  2025-09-18

  Explore the advanced applications of Rucaparib (AG-014699, PF-01367338), a potent PARP inhibitor, in DNA damage response and radiosensitization in PTEN-deficient and ETS-fusion expressing cancer models. This article highlights its mechanistic roles in base excision repair pathway inhibition and interprets emerging cell death signaling insights relevant to cancer biology research.

• Several ceritinib resistant mutations following the second l

  2025-03-03

  

  Several ceritinib-resistant mutations following the second-line treatment of ALK+-NSCLC have been discovered [64]. These mutations include C1156Y, F1174L, and L1152R, which were first observed in crizotinib-resistant tumor samples. The G1202R ceritinib-resistant mutation occurs within the hinge and

• br Introduction Psychostimulant abuse and

  2025-03-03

  

  Introduction Psychostimulant abuse and addiction remain a societal problem in the United States. The latest statistics from the National Survey on Drug Use and Health indicate that slightly less than one million people over the age of 12 report having a cocaine use disorder (NSDUH, 2016). Additio

• The rank order of agonist

  2025-03-03

  

  The rank order of agonist potency in turkey cardiac chambers demonstrated the predominant presence of the β-adrenergic receptor subtype, in line with the receptor classification by . However, a previous radioligand binding study in the left ventricles of 7-week old turkeys reported the existence of

• ACK has been clearly implicated in cancer progression in

  2025-03-03

  

  ACK1 has been clearly implicated in cancer progression in recent years. A strong correlation between ACK1 gene copy number, protein level and activity have been demonstrated in tumors of different tissue types (Mahajan et al., 2007; van der Horst et al., 2005; Wang et al., 2006). Our western blot a

• br Acknowledgement br Introduction There

  2025-03-03

  

  Acknowledgement Introduction There has been great progress in the treatment of autoimmune disease during the past several decades. However, the majority of autoimmune diseases have no known cure. B lymphocytes and autoantibodies play important roles in many autoimmune diseases, including rheum

• 5003 synthesis In an AP scenario several inflammatory mediat

  2025-03-03

  

  In an AP scenario, several inflammatory mediators are produced locally to orchestrate an immune response. Eicosanoids are among those molecules and represent a class of lipid mediators synthesized from arachidonic 5003 synthesis through the action of cyclooxygenases or lipoxygenases to generate pro

• 6656 Tumor suppressor ARF regulates the activity of p by inh

  2025-03-01

  

  Tumor suppressor ARF regulates the activity of p53 by inhibiting the functions of Mdm2. ARF is induced by hyperproliferative signals emanating from oncogenic Ras, overexpressed c-myc, and from deregulated E2F . ARF prevents p53 degradation and leads to increased p53 function by sequestering Mdm2 to

• br Concluding remarks It is clear

  2025-03-01

  

  Concluding remarks It is clear that a disordered l-arginine homeostasis by changes in arginase, NOS and ADMA activity and expression, is not only vital in the chronic airway diseases, rotenone and COPD, but also seems to play an important role in many co-morbidities. Unknown, however, is whether

• M871 In our approach using BRET and FRET there is

  2025-03-01

  

  In our approach using BRET and FRET, there is a substantial increase in BRET and FRET signals between Giα2 or Giα3-YFP and CFP- Gγ2/Rluc-Gγ2 upon apelin-13 activation, indicating that Gαi2, Gαi3 and N-terminus of Gβ1γ2 subunits become closer without subunit dissociation. In contrast, both the FRET a

• br Conflict of interest br Acknowledgments This work was fin

  2025-03-01

  

  Conflict of interest Acknowledgments This work was financially supported by the Fund Project of Sichuan Provincial Department of Education (16ZB0053), the Scientific Research Foundation of Sichuan Agricultural University (No. 06021400) and the China Postdoctoral Science Foundation (No. 2015M58

• fty The reasons why antibiotic treatment may

  2025-03-01

  

  The reasons why antibiotic treatment may be detrimental are diverse. First, it may result in disruption of multifaceted microbe–microbe, as well as microbe–host, interactions that are key for the maintenance of homeostasis within this ecosystem. This can lead to the expansion of pathogenic microorga

• Under some pathological conditions AT

  2025-03-01

  

  Under some pathological conditions, AT1R internalization is decreased when agonist exposure is prolonged. This weakens or removes the AT1R desensitization effect and leads to AT1R and downstream signal overactivation. AT1R overactivation can result in continued biological effects such as sustained v

• Finally intracrine androgen synthesis metabolism can be acti

  2025-03-01

  

  Finally, intracrine androgen synthesis/metabolism can be activated thus allowing hiv protease inhibitors to bypass the low levels of androgens in the circulation by producing androgens themselves (Cai and Balk, 2011, Rahman et al., 2004). Moreover, changes in AR co-regulators like the overexpression

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