• It is established that hypoxia can induce autophagy

  2019-06-14

  

  It is established that hypoxia can induce autophagy [32,34–37]. We evidenced the autophagic activation in the cultured human osteosarcoma MG-63 topoisomerase inhibitors after incubation in 1% O2 for 24h. The concomitantly elevated LC3 protein levels with HIF-1α high expression on OS tissue sections

• lpa receptor Introduction Schwannoma is a benign tumor of

  2019-06-14

  

  Introduction Schwannoma is a benign tumor of neuroectodermal derivation that originates from Schwann lpa receptor which cover the peripheral nerves [3]. Approximately 25–40% of all schwannomas occur in the head and neck. These tumors most commonly arise in the soft tissues of the head and neck and

• notch inhibitor Introduction Paraneoplastic immune mediated

  2019-06-14

  

  Introduction Paraneoplastic immune-mediated encephalopathy is a newly described disease. In 2005, Vitaliani et al first reported that four young women with ovarian teratoma (OT) had developed acute psychiatric and neurologic symptoms, e.g., seizures, memory deficits, decreased level of consciousnes

• br A KCNJ mutation corresponding to an S L

  2019-06-14

  

  A KCNJ8 mutation, corresponding to an S422L mutation in the protein, was first identified in a 14-year-old girl with early repolarization [59], who suffered frequent VF attacks. KCNJ8 encodes Kir6.1, which has 2 transmembrane regions, and the KATP channel is composed of a complex of Kir6.1 or Kir6

• br Discussion Prehabilitation is a program to enhance

  2019-06-14

  

  Discussion “Prehabilitation” is a program to enhance functional capacity and psychological health to enable patients to withstand an upcoming stressor, e.g. surgery. It is intended to reduce treatment-related morbidity and/or mortality, to decrease length of hospital stay and/or re-admission, and

• The main inherited arrhythmogenic causes of SCD in

  2019-06-14

  

  The main inherited arrhythmogenic causes of SCD in the young are summarized in Fig. 1. These arrhythmogenic disorders include familial long QT syndrome (LQTS), catecholaminergic polymorphic ventricular tachycardia (CPVT), Brugada syndrome (BrS), idiopathic ventricular fibrillation, early repolarizat

• Introduction Pulmonary vein isolation PVI is an established

  2019-06-14

  

  Introduction Pulmonary vein isolation (PVI) is an established strategy of paroxysmal atrial fibrillation (PAF) ablation [1–3]. Radiofrequency catheters have been the standard for AF ablation; however, PVI using balloon-based ablation has been increasingly adopted by electrophysiology laboratories a

• is a fastidious organism requiring specific nutritional atmo

  2019-06-14

  

  is a fastidious organism requiring specific nutritional, atmospheric, and temperature requirements for growth. For this reason culture capability might only be available in limited PICT microbiology laboratories. The use of multiplex PCR targeting common pathogens associated with genital ulceration

• br Although killed whole cell oral

  2019-06-14

  

  Although killed, whole-cell oral cholera vaccines (OCVs) have been known to be efficacious since 1986, and the bivalent whole-cell vaccine Shanchol has been licensed in India since 2009, OCV was not regarded as useful for controlling cholera outbreaks until recently. Many public health officials q

• br The west African outbreak of Ebola virus disease

  2019-06-14

  

  The 2014–15 west African outbreak of Ebola virus disease is unprecedented in scale, especially in Sierra Leone, which as of May 15, 2015, had reported 8598 confirmed cases and 3538 confirmed Ebola-related deaths. Sierra Leone\'s response to this emergency has been compromised by a fragile health s

• br An estimated million babies are born preterm annually

  2019-06-14

  

  An estimated 15 million babies are born preterm annually. Preterm birth complications account for more than 15% of deaths in children younger than 5 years and survivors often have long-term consequences with respect to their health, growth, and psychosocial functioning. The most beneficial interve

• Ya se alamos l neas arriba que el elogio respond

  2019-06-14

  

  Ya señalamos líneas arriba que el elogio respondía Spadin una tradición primordialmente masculina. Ese rasgo se reproduce, claro está, en la RF, lo cual se explica fácilmente por las redes de sociabilidad que nutrían a esta revista y que esbozamos al principio de este artículo. La única excepción qu

• La categorizaci n propuesta por Margaret Randall es mucho m

  2019-06-14

  

  La categorización propuesta por Margaret Randall es mucho más simple, puesto que distingue tan sólo entre aquellos testimonios en sí de los testimonios para sí. Christina Dupláa analiza tal distinción: Como puede verse, la clasificación es bastante difusa, ya que en la primera categoría se consider

• The diagnosis of PTC based

  2019-06-13

  

  The diagnosis of PTC, based on the Modified Dandy Criteria, is made when a patient exhibits an elevated LP opening pressure above 25cm H20 with normal CSF composition and radiologic findings, and no other explanation for the rise in intracranial pressure [6]. The most common presenting symptom occur

• However the patient was later re admitted

  2019-06-13

  

  However, the patient was later re-admitted with frequent palpitation symptoms similar to those exhibited prior to the initial RFCA. Despite oral class I antiarrhythmic drug and beta-blocker treatment, ECG revealed incessant ATs and symptomatic AF (Fig. 2), so repeat RFCA was performed. Intravenous b

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