• br Conclusions br Declaration of

  2020-12-15

  

  Conclusions Declaration of interest Acknowledgment This work was supported by an AIRC (Associazione Italiana Ricerca Cancro-Milan) Grant KFR062-2 to A.G.L, by Ricerca Funds by Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico (Grant No. 180/01) and by the ERA-NET “ERare” (Grant GO

• br Experimental procedures br Results Fluorescence attributa

  2020-12-15

  

  Experimental procedures Results Fluorescence attributable to GnRH-eGFP neurons was observed through the diagonal band of Broca, to the POA of the hypothalamus in GnRH-eGFP transgenic rats for all groups as described previously (Kato et al., 2003, Tada et al., 2013). Discussion The mEPSCs w

• br Materials and methods br

  2020-12-15

  

  Materials and methods Results We examined the effects of curcumin in Fluo-4 loaded SH-EP1 WM-8014 sale stably transfected with human α7-nACh receptor. Application of curcumin alone in the concentrations up to 100 μM for 30 sec. did not induce any detectable change in intracellular Ca2+ levels

• 2-NBDG The main advantage of exploiting paper sludges as sou

  2020-12-15

  

  The main advantage of exploiting paper sludges as sources of cellulose-derived energy and chemicals in comparison to other lignocellulose substrates is their amenability, which is associated with an extensive pulping process that removes the majority of the lignin and exposes 2-NBDG fibers to enzym

• Because of the lack of sequence current knowledge

  2020-12-15

  

  Because of the lack of sequence, current knowledge on the cellular regulation of CoA-IT is scarce. However, recent work has suggested an interesting new role for CoA-IT in regulating the extent of the AA mobilization response in primed macrophages. Bacterial lipopolysaccharide (LPS) is a poor trigge

• Many studies have documented that enolase acts as

  2020-12-15

  

  Many studies have documented that enolase acts as a plasminogen-binding protein and this interaction is involved in the tissue invasion and pathogenicity of the causative agents (Almeida et al., 2004; Avilan et al., 2000; Marcilla et al., 2007; Mundodi et al., 2008; Vanegas et al., 2007). Furthermor

• br EBV Infection Epstein Barr

  2020-12-15

  

  EBV Infection Epstein–Barr virus (EBV, human herpesvirus 4) was discovered 50 years ago, when Epstein, Achong, and Barr used electron microscopy to identify viral particles in Burkitt's lymphoma cells. It belongs to the lymphocryptovirus (LCV) genus of the gammaherpesvirus subfamily (Fig. 1A). Th

• Ginsenoside Rd australia br Introduction The Epstein Barr vi

  2020-12-15

  

  Introduction The Epstein–Barr virus induced gene 2 (EBI2 also known as GPR183) is a G protein-coupled seven-transmembrane (7TM) receptor that is predominantly expressed in B and T cells [1,2]. It regulates the trafficking of Ginsenoside Rd australia within lymphoid tissues and is highly importan

• Recent results from our group found

  2020-12-15

  

  Recent results from our group found that SPMs, not only play a part in terminating inflammation, but also have a physiological role in conjunctival goblet Probucol to maintain ocular surface health in the absence of disease. Amongst the SPMs that are effective in the conjunctiva are resolvin D1 (Rv

• br Materials and methods br

  2020-12-15

  

  Materials and methods Results Discussion Regardless of obvious beneficial effects of GC on acceleration of foetal lung and cardiomyocytes maturation (Kamath-Rayne et al., 2012; Rog-Zielinska et al., 2015), the current study revealed that GC exposure during late pregnancy induces IR and alte

• The DNA damage response DDR is

  2020-12-15

  

  The DNA damage response (DDR) is a cellular mechanism that protects against DNA damage induced by endogenous and exogenous factors, it includes changes in cellular processes such as BQ-788 sodium salt synthesis regulation, DNA damage repair, apoptosis and chromatin remodeling. In recent years, the

• Does a universal mechanism for

  2020-12-15

  

  Does a universal mechanism for TLS exist? Our previous studies using the bacteriophage T4 DNA polymerase generated the model provided in Fig. 7 that quantifies the molecular forces influencing key steps in the polymerization pathway during the replication of a non-instructional versus miscoding DNA

• br Results and discussion br Conclusion A

  2020-12-14

  

  Results and discussion Conclusion A new series of 2-mercapto-quinazolin-4-one analogues is designed and synthesized to possess electron withdrawing or donating functional groups (Cl or CH3O) at position 6- or 7-, 4-methoxyphenyl function at position 3. The 2-mercapto function is used to connec

• br Application of the screening system for ITP binding

  2020-12-14

  

  Application of the screening system for ITP-binding proteins Inosine is a nucleoside with hypoxanthine as a base. Inosine nucleotides are relatively abundant in human 2-D08 because inosine monophosphate (IMP) is a general precursor molecule for the de novo synthesis of AMP and GMP or a product o

• Cytochrome P CYP enzymes plays an essential

  2020-12-14

  

  Cytochrome P450 (CYP-450) enzymes plays an essential role in pharmacology of drugs and toxicology of xenobiotics. Inhibition of these enzymes may lead to increase plasma levels of a concomitantly administered drug (Lee et al., 2013). It may prolong or reduce the pharmacological effects and increase

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