• The mechanism by which these HIV PIs impair

  2021-06-01

  

  The mechanism by which these HIV-PIs impair skeletal muscle palmitate transport and oxidation has been partially elucidated. CD36 (also referred to as fatty 5-BrdU translocase; FAT) is a transmembrane protein involved in the transport of long-chain fatty acids (LCFA) across cellular membranes. It h

• Two major mechanisms including apoptosis and oxidative stres

  2021-06-01

  

  Two major mechanisms including apoptosis and oxidative stress have been suggested for MTX-induced cytotoxicity (Hafez et al., 2015; Neuman et al., 1999; El-Sheikh et al., 2015). It has been reported that MTX promotes cell death via apoptosis in both cancerous and non-transformed cells (Mazur et al.,

• Abha et al reported Natural coumarinolignoids isolated from

  2021-06-01

  

  Abha et al. reported Natural coumarinolignoids isolated from the seeds of Cleome viscosa consist of a racemic mixture of cleomiscosins A 19, B 20 and C 21 and were screened for anti-inflammatory activity through mol. docking and QSAR studies by using reported in vivo activity of Swiss albino mice. B

• br Bipartite graph br Algorithm for CFC br Error

  2021-06-01

  

  Bipartite graph Algorithm for CFC Error detection rate and overhead evaluation Test results and discussion For verifying the proof in L-Kynurenine receptor from the perspective of practice, this section brings tests and analysis based on the onboard computer (OBC) of the in-service ZDPS-

• br Methods br Results and discussion br Conclusions br

  2021-05-31

  

  Methods Results and discussion Conclusions Conflict of interest Acknowledgment The research is supported by the National Natural Science Foundation of China (Grant No. U1603285). Overview of the MAPK pathway The mitogen-activated protein kinases (MAPK) pathway, often known as a ca

• Mevastatin At one time the biological effects of cAMP were

  2021-05-31

  

  At one time, the biological effects of cAMP were thought to be mediated exclusively by Protein Kinase A (PKA). Consistent with this, PKA inhibitors have been shown to reverse the effects of cAMP-elevating agents on VSMC proliferation [5]. However, we recently reported that cAMP-mediated inhibition o

• Since ET was discovered first and showed a wide

  2021-05-31

  

  Since ET-1 was discovered first and showed a wide variety of actions not only on the cardiovascular system but also on various other tissues, much information has accumulated on ET-1 compared with the two other peptides. The method for measurement of ET-1 levels in plasma or various tissues by means

• In conclusion our findings demonstrated that S PC augments H

  2021-05-31

  

  In conclusion, our findings demonstrated that S1PC augments HMOX1 expression in a NO-dependent manner, and its effects are associated with the enhancement of BACH1 degradation. In addition, S1PC and NO potentially degrade BACH1 based on the observation that nuclear degradation of BACH1 differs from

• br Materials and methods br Results br Discussion Our

  2021-05-31

  

  Materials and methods Results Discussion Our results based on the Y2H analysis between the U-box-motif region of E3s and the UBC domain of E2s showed that, among 40 rice E2s, 11 E2s accounted for 70% of the interactions with 17 ARM-U-box E3 Ub-ligases (Fig. 2, Fig. 3). These 11 E2s belong t

• E is a classical initiator protein

  2021-05-31

  

  E1 is a classical initiator protein and, as such, plays several roles in the initiation and catalysis of viral DNA synthesis. E1 must first recognize a specific segment of the viral YM201636 known as the “origin of DNA replication”, or “ori” for short. For most PV types examined to date, the minimal

• Although PD is traditionally viewed as a motor disorder evid

  2021-05-31

  

  Although PD is traditionally viewed as a motor disorder, evidence from numerous epidemiologic (Shiba et al., 2000) as well as case–control studies (Richard, 2005) suggest the occurrence of non-motor symptoms including hyposmia/anosmia, gastrointestinal disturbances, sleep abnormalities, autonomic dy

• In children only the genotype was associated with spina bifi

  2021-05-31

  

  In children, only the 6/7 genotype was associated with spina bifida, increasing the risk about 4 times relative to the DHFR 3/3 and 6/6 genotypes. However, the 95%CIs are broad and only few spina bifida patients have the DHFR 6/7 genotype. The effect of the 6/7 genotype on spina bifida risk is there

• Our data show a site specific interaction of

  2021-05-31

  

  Our data show a site-specific interaction of DDR2 with collagen II. This indicates that the DDRs recognise a particular sequence within collagen and not simply the collagenous triple helix per se. This common tertiary structure of all collagens is formed by three α chains, each with a repeating G-X-

• Addition of deoxyuridine to CY

  2021-05-31

  

  Addition of deoxyuridine to CY11 cultures led to a significant decline in the amount of uracil-DNA (Fig. 5). Deoxyuridine effectively induces the deo operon and is efficiently degraded to uracil and deoxyribose 1-phosphate by the deoA gene product, thymidine phosphorylase; a minor percentage of deox

• Xenobiotic metabolism primarily occurs in liver

  2021-05-31

  

  Xenobiotic metabolism primarily occurs in liver, which contains many enzymes to catalyze the transformation of xenobiotic. Usually, cytochrome P-450s (CYP450s) act as the first response for biotransformation of xenobiotic in organisms. CYP450s generally consist of various subfamily enzymes which can

15347 records 622/1024 page Previous Next First page 上5页 621622623624625 下5页 Last page