• The replenishment time course of already

  2022-01-26

  

  The replenishment time course of already-tethered vesicle to became release ready, was examined by TIRFM imaging combined with calcium uncaging. By UV-flash photolysis of caged calcium, intracellular calcium concentration raises rapidly and homogenously throughout the cell (Ellis-Davies, 2008). Upon

• The effects of C on the NF B pathway

  2022-01-26

  

  The effects of C646 on the NF-κB pathway could be explained by the role for p300 that has been described in the regulation of the NF-κB pathway [5]. For instance, acetylations of the p65 NF-κB subunit on lysines 218, 221 and 310 are mediated by the HATs p300 and PCAF [11] and increase transcriptiona

• Given the role that activation of GC C has

  2022-01-26

  

  Given the role that activation of GC-C has in stimulating fluid secretion in the intestine, attempts have been made to exploit this pathway to relieve symptoms of chronic constipation. Currently, an orally administered synthetic ST mimic, linaclotide [29], has been successfully shown to alleviate co

• Introduction Molecular imprinting technology is a

  2022-01-26

  

  Introduction Molecular imprinting technology is a method that combines the material chemistry, biochemistry, and polymer chemistry and has the ability to specifically identify target analytes on shape, size and functional groups. Molecular imprinting polymer (MIP) is developed based on molecular im

• Because of the relationship between

  2022-01-25

  

  Because of the relationship between carbohydrate consumption and chronic diseases such as obesity and type II diabetes (Hu, van Dam, & Liu, 2001), there is mounting interest to evaluate the quality of Ozagrel HCl through analysis by glycemic index (GI) and Englyst assay, for example (Englyst, Kingm

• Cartilage and subchondral bone synovial tissue interactions

  2022-01-25

  

  Cartilage and subchondral bone/synovial tissue interactions are well-recognized features of joint failure and osteoarthritis[17](seeFig. 1A, B). The intimate mechanical and biological interactions between these tissues are likely to alter the structural organization and function of either tissue. Ho

• br Conclusions In this study we discovered that

  2022-01-25

  

  Conclusions In this study, we discovered that the G-quadruplex (Q1) formed by S1 sequence in the upstream region of the transcription start site of c-Myb gene functioned as a positive transcriptional regulator, which was different from the most cases that G-rich sequences functioned to impair the

• Sperm capacitation was negatively r p related with CR while

  2022-01-25

  

  Sperm capacitation was negatively (r = −0.68; p ive but not significant (r = 0.22). No significant relationship was observed between the expression levels of either CB1 receptor or FAAH and any of the sperm quality parameters studied. The scatter plot distribution of spermatozoa expression of CB1 an

• br STAR Methods br Acknowledgments We thank the

  2022-01-25

  

  STAR★Methods Acknowledgments We thank the Shanghai Synchrotron Radiation Facility (SSRF) BL18U for help with X-ray data collection. We thank Dr. Thomas F.J. Martin for providing the pcDNA3.1-CAPS-1 plasmid and Dr. Xiaofei Yang for providing the pFHUUIG_shortU6 (l309) plasmid. We thank Dr. Shun

• YAP TAZ nuclear function is also influenced by

  2022-01-25

  

  YAP/TAZ nuclear function is also influenced by interaction with the TEAD family of transcription factors [96, 97, 98, 99, 100, 101]. The RAC1 acetylcholinesterase inhibitor exchange factor protein TIAM1 has recently been linked to YAP/TAZ regulation in the nucleus and cytoplasm. Nuclear TIAM1 inhib

• br Materials and methods br Results To

  2022-01-25

  

  Materials and methods Results To examine the time and organ specific effect of normal photoperiod and dark environment on the DRB of different SlHXKs and on the enzyme activities, these parameters were determined in different leaf positions of tomato plants. Under control conditions, transcri

• A few animal and cell culture studies have been

  2022-01-25

  

  A few animal and cell culture studies have been reported that the reason of HCV-related hepatic steatosis in CHC infection is mainly HCV core protein (Chang et al., 2007; Perlemuter et al., 2002; Ferré, 2004). HCV core protein inhibits activities of microsomal triglyceride transfer protein (MTP) and

• Additionally molecular imaging has great potential for nonin

  2022-01-25

  

  Additionally, molecular imaging has great potential for noninvasive and quantitative imaging of pancreatic β-cells, but each single imaging modality has its own intrinsic strengths and limitations. Functional imaging modalities have high sensitivity (such as SPECT and PET) and anatomical imaging tec

• Flavonoids are able to modulate proinflammatory signaling pa

  2022-01-24

  

  Flavonoids are able to modulate proinflammatory signaling pathways to prevent OS and apoptosis [139]. Paraoxygenase-2 (PNO2) is an enzyme involved in neuroprotection by preventing OS mediated damage in mitochondria. Flavonoids can modulate the JNK/AP-1 pathway to increase expression of PNO2 [111]. F

• br Methods br Acknowledgements The

  2022-01-24

  

  Methods Acknowledgements The authors thank the ZLS group members, particularly Li Li and Elijah Roberts, for many helpful discussions. They also wish to thank Nathan Baker for APBS assistance, Jan Jensen for help with PROPKA 2.0, Susan Martinis for experimental interpretations, and John Stone

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