• In young animals the HT

  2025-02-01

  

  In young animals, the 5-HT2A Protein labeling reagent antagonist ketanserin, at relatively low concentrations, shifted 5-HT concentration-response curves rightward, suggesting a role for 5-HT2A receptors in mediating 5-HT-induced contractions of the ureter. The slopes of the ketanserin Schild plots

• br Autophagy inducers Macroautophagy is often

  2025-02-01

  

  Autophagy inducers Macroautophagy is often seen as a cellular process capable of increasing the fitness of lysophosphatidic acid mg and overcome resistance to several forms of stress [9], [10]. As discussed above, it has been proposed by several authors that an effective strategy for enhancing se

• Here we provide evidence that NO contributes to changes in

  2025-01-31

  

  Here, we provide evidence that NO contributes to changes in synaptic strength, but also offer an explanation as to why previous attempts to link NO to LTP have often failed. Our results describe a model by which cycling AMPARs, held in intracellular pools, are rapidly delivered to the membrane surf

• The functional significance of the cap residues with regard

  2025-01-31

  

  The functional significance of the cap residues with regard to the established role of PfA-M1 in hemoglobin catabolism in the food vacuole is a key question that is difficult to address with in vitro studies. We note that three of the dipeptide substrates used in our study are found in the sequences

• The beneficial treatment with several statins have been eval

  2025-01-31

  

  The beneficial treatment with several statins have been evaluated in AD patients (Kivipelto et al., 2005), with controversial results. It has been suggested that statins slow cognitive decline in mild to moderate AD (Miida et al., 2005). Treatment with atorvastatin, combined with other medications,

• The G R mutation is located at the solvent front

  2025-01-31

  

  The G1202R mutation is located at the solvent front of the ALK kinase domain adjacent to the inhibitor's binding pocket. Although barely reported in the setting of crizotinib resistance, it has emerged as the most refractory mutation to both the first- and second-generation ALK inhibitors. The large

• Gliomas and Aldehyde Dehydrogenase Aldehyde

  2025-01-31

  

  Gliomas and Aldehyde Dehydrogenase Aldehyde dehydrogenases (ALDHs) are key metabolic enzymes involved in regulation of glycolysis/gluconeogenesis pathways as well as in the detoxification of endogenous and exogenous aldehydes, regulating cell function and homeostasis. ALDHs play important roles in

• br Concluding Remarks and Future Directions The physiologica

  2025-01-27

  

  Concluding Remarks and Future Directions The physiological significance of autophagy in neuronal function is steadily emerging. The studies discussed herein reveal that key neuronal functions, such as neurotransmitter release, pruning of dendritic spines, and behavioural outputs of neural network

• Roles of Aurora kinases in directly activating

  2025-01-27

  

  Roles of Aurora kinases in directly activating multiple oncogenic pathways and promoting proliferation as well as transformation have also been demonstrated. Aurora-A has been shown to up-regulate telomerase reverse transcriptase mRNA through c-myc [26]. The kinase was also implicated in activating

• Cryptotanshinone synthesis br Conflict of interest br

  2025-01-27

  

  Conflict of interest Acknowledgments This work was been partially supported by the following grants: C.I.S.I.A. project (Innovazione e Sviluppo del Mezzogiorno—Conoscenze Integrate per Sostenibilità ed Innovazione del Made in Italy Agroalimentare—Legge 191/2009) from the Italian Ministry of Ec

• exemplifies three of the compounds investigated in the

  2025-01-27

  

  exemplifies three of the compounds investigated in the selection for a candidate drug (CD). Our first criteria was an IC The ATRA as such did not show any genotoxicity in the SOS/umu assay, but this does not say anything about any possible genotoxicity of its metabolites or degradation products. A

• br Material and methods br

  2025-01-27

  

  Material and methods Results Discussion Although we were not able to detect 12/15-LOX mRNA in the lungs of 12/15-LOX knockout mice substantial amounts of 15-HETE could be detected in BALF. In fact, significant synthesis of 15-HETE in 12/15-LOX mice have been already reported [17]. The redun

• Chromatin proteins play important roles in gene expression a

  2025-01-27

  

  Chromatin proteins play important roles in gene expression and DNA repair. The importance of chromatin composition on gene expression is exemplified by X-inactivation, where one of the two X chromosomes in female mammalian Vincristine is transcriptionally silenced by heterochromatin , , , . In the A

• The compounds containing beryllium act as strong Lewis acids

  2025-01-27

  

  The compounds containing beryllium act as strong Lewis acids because of electron deficiency of the Be Combretastatin A4 []. Interactions of X-Be-Y compounds with different Lewis bases have been studied by Yanez and co-workers [], extensively. Recently, they proposed a class of extremely strong bide

• Furthermore we also found that the basic level of ROS

  2025-01-27

  

  Furthermore, we also found that the basic level of ROS was markedly lower in mtDNA-reduced SW480 fura mg than that in the parent cells. Endogenous ROS is most notably produced at the sites of complex I and complex III [5], it might be plausible that the decreased quantity of ROS observed in mtDNA-r

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