• Adiponectin is an adipokine whose

  2024-06-06

  

  Adiponectin is an adipokine whose circulating level is depleted in a number of metabolic diseases including insulin resistance, diabetes and cancer (Khan et al., 2015, Singh et al., 2014a, Singh et al., 2014b, Yamauchi et al., 2014). Despite its importance in health and pathophysiology, adiponectin

• Streptomycetes are a group of filamentous Gram

  2024-06-06

  

  Streptomycetes are a group of filamentous Gram-positive, soil-inhabiting bacteria which have captured enormous screening interest because of their ability to produce and secrete a variety of MHY1485 and extracellular proteins [7]. Among the diverse antibiotics produced by Streptomycetes are the nuc

• GMF was later localized to the cytosol of

  2024-06-06

  

  GMFβ was later localized to the cytosol of primary astrocytes and glioma cell lines [67], prompting investigations into its involvement in intracellular signaling. It was found that PKA phosphorylation of GMFβ inhibits the ERK1/2 branch of the MAP kinase pathway [73], yet activates the stress-respon

• Two patients developed diffuse mesangio proliferative glomer

  2024-06-06

  

  Two patients developed diffuse mesangio-proliferative glomerulonephritis (DMPG) postoperatively, presenting as nephrotic syndrome and benign haematuria, respectively. DMPG has been reported in an adult patient with thymomatous MG following thymectomy [35], and various types of glomerulonephritis hav

• NLX a k a F

  2024-06-06

  

  NLX-112 (a.k.a. F13640 or befiradol), exhibits nanomolar affinity at 5-HT1A receptors, and, in 49 9 to the 5-HT1A receptor agonists listed above, it presents exceptional selectivity and high efficacy at these receptors (Colpaert et al., 2002, Newman-Tancredi et al., 2017). Additionally, it has show

• The initial observations indicating a crucial role for elect

  2024-06-06

  

  The initial observations indicating a crucial role for l arabinose transfer in 17,20 lyase activity were that the molar ratio of POR to P450c17 is three- to four-fold higher in porcine testes than in porcine adrenals, and that adding purified POR to porcine P450c17 in vitro increased 17,20 lyase mo

• The tumor suppressor function of LOX in normal prostate epit

  2024-06-05

  

  The tumor-suppressor function of 15-LOX-2 in normal prostate epithelial cells may be explained by the induction of replicative senescence [14,15]. Thus, 15-LOX-2 is overexpressed in age-dependent prostatic hyperplasia, but cell senescence may hinder progression to malignant transformation. Notwithst

• Findings of the present study provide

  2024-06-05

  

  Findings of the present study provide a molecular mechanism for the elevated ASK1 expression in obesity and how it may be functionally linked to whole-body insulin resistance. The role our findings assign to increased E2F1 in upregulating ASK1 parallels the capacity of this transcription factor to r

• Arginase deficiency is a rare urea cycle disorder with hyper

  2024-06-05

  

  Arginase deficiency is a rare urea cycle disorder with hyperargininemia and profound neurological impairment as hallmark features. Arginase-1-deficient mouse models have been created, and they exhibit a profound lethal phenotype approximately 2 weeks after birth in the global knockout (KO) mice or a

• br Materials and Methods br Author

  2024-06-05

  

  Materials and Methods Author Contributions Conflicts of Interest Acknowledgments We thank Francine Jodelka for technical assistance and Gopal Thinakaran for the CTM-1 antibody. This work was financially supported by RFUMS internal research funding and NIHS10 OD 010662. Introduction A

• PGC mediated mitochondrial biogenesis in brown fat and

  2024-06-05

  

  PGC-1α-mediated mitochondrial biogenesis in brown fat and endothelial hyPerFUsion™ high-fidelity DNA polymerase is in part regulated by eNOS and NO [28], [29]. Recent studies indicate that H2S not only augments NO bioavailability and signaling [11], [17], but provides protection against cardiac inj

• br Experimental section br Introduction

  2024-06-05

  

  Experimental section Introduction NMDA receptor-induced increases in AMPAR trafficking to the synaptic surface mediates changes in synaptic efficacy in a number of Cy3 RNA regions (Shi et al., 1999, Sun et al., 2005, Frenkel et al., 2006). While this process has been linked to the regulated i

• Nutritional factors affecting ASD have also recently receive

  2024-06-04

  

  Nutritional factors affecting ASD have also recently received attention. An increase in postsynaptic zinc (Zn) level induced by clioquinol (a Zn chelator and ionophore), and the subsequent activation of NMDA receptors through the tyrosine kinase Src, rescued social interaction in Shank2−/− mice (Lee

• br Roles for GMF in Endocytic Traffic In addition

  2024-06-04

  

  Roles for GMF in Endocytic Traffic In addition to its roles in cell migration, GMF regulates actin-dependent endocytosis in yeast and mammals 13, 14, 50, and promotes the turnover of focal adhesions in immune BMS-754807 42, 51. Vinculin, a central component of focal adhesions that anchors cells t

• Our second patient years old

  2024-06-04

  

  Our second patient, 42years old male, a farmer, was all right when he went to sleep, but noticed drooping of eyelids and swallowing difficulty when he woke up. He later developed flaccid weakness of all four limbs and was quadriplegic when he was wheeled into the emergency room. He was tachypneic a

14918 records 107/995 page Previous Next First page 上5页 106107108109110 下5页 Last page